Sr Modeling Staff Eng

Date Posted: 6/13/2025

Senior Modeling Staff Engineer
(Synthetic Molecule Process Development)
Boston, MA (onsite)

Top tier pharmaceutical company looking to hire a Senior Staff Engineer, Modeling, someone with a strong background in chemical engineering that can handle and lead challenging problems in chemical reactions using their expertise in reaction kinetics, transport phenomena, mathematical modeling, and reactor design.

Responsible for leading and developing the scale-up and scale-down models for studying unit operations using both first-principle and data-based models. This includes the application of process analytical technologies combined with mathematical models (statistical & first principle) to enhance process understanding. This will enable the development, optimization, scale-up, and troubleshooting of processes using in-silico approaches.

If you’re looking to join a dynamic and innovative team of engineers and scientists within Synthetic Molecule Process Development to develop robust and cost-effective processes for the manufacture of new small molecule pharmaceuticals, along with methods for achieving and controlling high standards of purity and quality, please take a look below.

Description:
In this role you will utilize advanced process modeling tools and digital twin functionalities, implementing model-based design of experiments for process characterization and risk assessment. Lead and contribute to the design, development, optimization, and scale-up of manufacturing processes for synthetic molecule drug substances using process modeling and simulation principles. This includes experimental designs and workflows for model development, validation, and verification. In collaboration with cross-functional and external partners to develop and deploy digital twins of unit operations. Work with Automation, Manufacturing, Process Engineers, and PAT experts to develop modeling and simulation (M&S) solutions that can be deployed across the global organization for in-silico process design, development, and optimization. Recommend, justify and implement in silico tools and an "in-silico first” approach to process development. Contribute to the democratization of modeling and simulation tools & results within global Synthetic Molecule Process Development. Develop project or significant technical strategy and leverages technical skill(s) as a resource expert within the department. Must contribute significantly and independently to project work as well as the development of platforms, which may include multiple projects within functional area. Analyze technical issues and coordinate potential resolutions with project team members based on model and simulation predictions. Review, interpret and communicate data cross functionally within pharmaceutical sciences and project teams. Significant technical responsibility for a project area technical program within the department and potentially across Pharmaceutical sciences. Stay current in novel process modeling and simulation tools and platforms, identify process trends and defines champions process strategy. Influence and support initiatives related to driving scientific and technical improvement within the function and potentially cross-functionally. Identify topics for initiatives and lead local/global initiatives on behalf of senior staff. Author relevant sections of regulatory documents, validation plans, reports and peer reviewed manuscripts. Identify vendors and build relationships to gain access to technologies as needed to deliver on pipeline and platform technology goals. Manage key vendor relationships across multiple projects as appropriate, and proactively affects resolution of issues arising at vendors. Represent the client and be an active member on pre-competitive collaborations with academic and industrial partners.

Required:
Master's degree in Chemical Engineering or a related pharmaceutical science with 8+ years of relevant industry experience. Ph.D. or postdoctoral fellowship in Chemical Engineering or a related pharmaceutical science with 2-3+ years of relevant industry experience. Strong experience and understanding of chemical reaction engineering and catalysis, with proven ability to demonstrate skills in these fields. Must have full understanding of transport phenomena and thermodynamics. Strong experience with commercially available reaction kinetic modeling software such as Ansys, ReactionLab, Dynochem, and gPROMS. Strong experience with software for computational fluid dynamics (CFD) modeling such as Ansys, Star CCM+, MStar CFD. Proficient in communication and data collection from systems such as sensors, controllers, and industrial systems.
Some experience with Matlab, Python, R, SQL, and good coding practices.

Additional preferred requirements:
Common statistical methods, basic data science principles, and AI/ML methodologies. Hands-on experience in wet lab process development. Experience in multivariate analysis and Principal Component Analysis (PCA). Understanding of synthetic molecule process development activities and current Good Manufacturing Practices (cGMP). Subject matter expertise and knowledge of applicable process modeling and simulation tools.

Position can provide full relocation assistance if needed. Base salary up to $160,000 base plus 20% bonus, LTI and full benefits.

Please contact Darren Gutowski at dgutowski@clarkdavis.com